Tretizen 20 Zenlabs


Manufacturer: Zenlabs Substance: Isotretinoin (Accutane) Pack: 20mg (10 capsules)

Additional information




Isotretinoin is for acne treatment. Promotes the normalization of terminal differentiation of cells, inhibits the hyperproliferation of the epithelium of the excretory ducts of the sebaceous glands, the formation of detritus and facilitates its evacuation. Due to this, the production of sebum decreases, its isolation is facilitated, the composition is normalized, the inflammatory reaction around the glands is reduced. With external and systemic application it has antiseboric, sebostatic, anti-inflammatory, kerato-and immunomodulatory effects; Strengthens the regeneration processes in the skin.

Dosage and administration

Inside, the recommended dose is 0.5-2 mg / kg, divided into two parts; Applied within 15-20 weeks. For most patients, a sufficient initial dose is 0.5 mg / kg / day, with severe disease or torso 2 mg / kg / day. Dose adjustment is performed depending on the response to therapy and / or the severity of side effects. If the amount of rashes decreased by 70% or more in 15-20 weeks, the treatment is stopped. The second cycle of therapy is carried out with an interval of at least 2 months with confirmation of a persistent or recurrent cycle of the disease.

Special instructions

During the therapy, it is necessary to control the level of lipids, glucose, liver function; Insolation should be avoided.

Isotretinoin side effects

Arthralgia, myalgia, pain in the chest, rash (erythema, seborrhea, eczema), thinning of hair – rarely, intracranial hypertension, mental disorders (depression, inclination to suicidal attempts), vasculitis (including Wegener’s granulomatosis) , Dry eyes, decreased night vision, cataracts, conjunctivitis, keratitis, enteritis.


Incompatible with retinoids, which exert keratolytic and exfoliative action.

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