Ekovir John Lee


Manufacturer: John Lee Substance: Acyclovir (Zovirax) Pack: 200mg (30 pills)

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Additional information




Ekovir (Acyclovir) is highly selective against human herpes viruses (including Herpes simplex type 1 and type 2), the Varicella zoster virus, the Epstein-Barr virus and cytomegalovirus. The mechanism of antiviral activity is to suppress the replication of viruses through competitive interaction with viral thymidine kinase, inhibition of DNA polymerase and blockade of viral DNA replication.

With herpes prevents the formation of new elements of the rash, reduces the likelihood of cutaneous dissemination and visceral complications, accelerates the formation of crusts, reduces pain in the acute phase of herpes zoster. The drug has an immunostimulating effect.


Ekovir (Acyclovir) is not absorbed from the gastrointestinal tract completely (about 20% of the dose taken), regardless of food intake. The maximum concentration is reached after 1,5-2 hours. Binding to plasma proteins is insignificant (9-33%). Little is metabolized by the liver.

Penetrates through blood-brain and placental barriers, excreted in breast milk. It is excreted by the kidneys through glomerular filtration and tubular secretion: 85-90% unchanged, 10-15% – in the form of a metabolite (9-carboxymethoxymethylguanine). The elimination half-life is about 3 hours. If the renal function is impaired (glomerular filtration deteriorates), the elimination half-life increases. With a decrease in glomerular filtration below 10 ml / min, the dose of acyclovir should be adjusted downward.

Side effect

Possible headache, dizziness, fatigue, dyspnea, nausea, vomiting, diarrhea, intestinal colic, fever, transient increase in the blood of bilirubin, urea, creatinine, hepatic transaminase activity, allergic reactions (skin rash, itching), lymphocytopenia.

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