Cernos Gel (Testogel) Sun Pharmaceuticalsceuticals

$63.00

Manufacturer: Sun Pharmaceuticalsceuticals Substance: Testosterone supplements Pack: 14 sachet per box

Additional information

Manufacturer

Package

Substance

Active ingredient: Testosterone Gel
Brand: Androgel / Andractim / Testim Gel
Indian analog: Cernos Gel
Manufacturer: Sun Pharmaceutical
Form release: One-time sachet 5 grams.

Characteristics

  • Testosterone Gel for external use 1%.
  • Excipients: ethanol 68.9%.
  • Each gram in the sachet contains 10 mg of Testosterone Gel.

Cernos Gel (Testogel) should be used only if testosterone deficiency is accompanied by such clinical manifestations as regression of secondary sexual characteristics, changes in body structure, asthenia, decreased libido, erectile dysfunction.

Pharmacodynamics

Endogenous androgens, mainly testosterone, secreted by the testicles, and their main metabolite, dihydrotestosterone, are responsible for the development of external and internal genital organs and the preservation of secondary sexual characteristics (stimulation of hair growth, coarsening of the voice, development of the libido). They affect the anabolism of proteins; Development of skeletal muscles and distribution of subcutaneous fat; Reduce urinary excretion of nitrogen, sodium, potassium, chlorides, phosphates and water. Testosterone does not cause development of testicles: it reduces the pituitary secretion of gonadotropins.

The effects of testosterone on certain target organs are manifested after the peripheral conversion of testosterone to estradiol, which then binds to estrogen receptors in the target cell nuclei (such as the pituitary gland, adipose tissue, brain, bones, etc.).

Pharmacokinetics

The degree of absorption of testosterone through the skin varies between 9-14% of the applied dose. After absorption through the skin, testosterone enters the systemic circulation at relatively constant concentrations for 24 hours.

Concentrations of testosterone in the serum increase from the 1 st h after application of the drug, reaching a constant value from the 2nd day of treatment. Daily fluctuations in testosterone concentrations have the same amplitude as the changes in endogenous testosterone content observed in circadian rhythms. With the external route of administration of the preparation, there are no supraphysiological peaks of testosterone concentration in the blood arising from the injection method of administration

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