Aldactone 100 RPG

Aldactone 100 belongs to a class of diuretics that conserve potassium and magnesium. A noticeable diuretic effect on the body appears in most cases on the second day of treatment, sometimes the therapeutic effect has to wait up to five days. At reception the organism is capable to process up to 90% of percent of active substance that speaks about good absorption of a preparation.

Pharmachologic effect

A potassium-sparing diuretic, whose action is caused by antagonism with aldosterone (MCN hormone of the adrenal cortex), which facilitates the inverse absorption of Na + in the renal tubules and the excretion of K +. Spironolactone (active ingredient of Aldactone) is a competitive antagonist of aldosterone in its effect on distal nephron sections (competes for binding sites on cytoplasmic protein receptors, reduces synthesis of permeases in the aldosterone-dependent region of collecting ducts and distal tubules), increases the excretion of Na +, Cl- and water and Reduces the excretion of K + and urea, reduces the titratable acidity of urine. Strengthening diuresis causes a hypotensive effect, which is unstable. The diuretic effect is manifested on the 2nd-5th day of treatment.

Pharmacokinetics

After oral intake absorbed from the digestive tract, absorption is 90%. Metabolized in the liver, the main active metabolite is canrenone.
T1 / 2 is 13-24 hours. It is excreted mostly by the kidneys, a certain amount is excreted with bile.

Contraindications

Addison’s disease, hyperkalemia, hypercalcemia, hyponatremia, chronic renal failure, anuria, hepatic insufficiency, diabetes mellitus with confirmed or suspected chronic renal failure, diabetic nephropathy, I trimester of pregnancy, metabolic acidosis, menstrual cycle or breast enlargement, hypersensitivity to spironolactone